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樊代明院士等人涉嫌剽窃国外综述

作者：igor

　　最近搜索关于食管癌的文章时，无意看到两篇问题都是“The molecular 
mechanisms of esophageal cancer”的综述，从题目，摘要，关键词，正文十
分雷同。后发表的是咱院士樊代明作为通讯作者的文章，请读者辨别。

 The molecular mechanisms of esophageal cancer 

Yunping Zhao1,2, Ruwen Wang2, Daiming Fan1,* 
EXCLI Journal 2006;5:79-92 

Esophageal Cancer ranks among the 10 most frequent cancers in the world, 
and recent evidence shows that its incidence is increasing. Prognosis 
of this disease is poor, with an overall 5-year survival rate of less 
than 10%. Unraveling the mechanisms or developing animal models for 
esophageal carcinoma have thus far not been successful. Many genes 
have been found that are believed to play a role in the development of 
esophageal cancer but the underlying mechanism by which this disease 
develops is still not clear. It is believed that esophageal cancer has 
an intricate molecular mechanism of evading apoptosis by the 
down-regulation of Bax, up-regulation of Bcl-2, Bcl-xl and Survivin, 
mutation of p53 and alteration in Fas expression. A great deal of 
research has been performed in order to determine the key genes that 
initiate and promote the growth of esophageal cancer. This review 
focuses on apoptosis and candidate genes linked to the development of 
esophageal cancer, which it is hoped may provide diagnostic and 
therapeutic tools, and potential therapeutic strategies for the 
management of this carcinoma. 

The molecular mechanisms of oesophageal cancer
M.L. McCabe, Z. Dlamini* 
International Immunopharmacology 5 (2005) 1113– 1130 

Apoptosis is a process of programmed cell death, which is as essential 
as cell growth, for the maintenance of homeostasis. When these 
processes loose integration such as cancer, then uncontrolled cell 
growth occurs. Cancer of the oesophagus ranks as the ninth most common 
malignancy in the world, and recent evidence shows that its incidence 
is increasing. Prognosis of this disease is poor, with an overall 
5-year survival rate of less than 10%. Unraveling the mechanisms or 
developing animal models for oesophageal carcinoma have thus far not 
been successful. It is believed that oesophageal cancer has an 
intricate molecular mechanism of evading apoptosis by the 
down-regulation of Bax, up-regulation of Bcl-2, Bcl-xl and Survivin, 
mutation of p53 and alteration in Fas expression. A great deal of 
research has been performed in order to determine the key genes that 
initiate and promote the growth of oesophageal cancer. This review 
focuses on apoptosis and candidate genes linked to the development of 
oesophageal cancer, which it is hoped may provide diagnostic and 
therapeutic tools, and potential therapeutic strategies for the 
management of this carcinoma.

(XYS20070616)

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